News brief
Jim Wappes
Topics
Salmonella
Foodborne Disease
![CDC ends probe of Salmonella cases tied to Papa Murphy's cookie dough (1) CDC ends probe of Salmonella cases tied to Papa Murphy's cookie dough (1)](https://i0.wp.com/www.cidrap.umn.edu/sites/default/files/Chocolate%20chip%20cookie%20dough-my_amii.jpg)
After 26 cases and 4 hospitalizations in six states, the Centers for Disease Control and Prevention (CDC) yesterday declared its investigation over into aSalmonellaoutbreak tied to raw cookie dough sold at Papa Murphy's pizza outlets. The CDC noted an increase of 8 cases and 2 hospitalizations since it first reported the outbreak in May.
Patients range in age from 14 to 81 years, with a median age of 48. Of the 26 patients, 21 (81%) are female. Illness-onset dates range from February 24 to May 28. None of the illnesses proved fatal. Oregon reported the most cases (8) followed by Washington (6), Idaho (5), Utah (4), California (2), and Missouri (1).
The true number of sick people in this outbreak was likely much higher.
"The true number of sick people in this outbreak was likely much higher than the number reported, and the outbreak may not have been limited to the states with known illnesses," the CDC said. "This is because many people recover without medical care and are not tested for Salmonella."
Dough should not be eaten raw
Of the 22 case-patients interviewed, 17 reported eating food from Papa Murphy's. Of those, 15 ate Papa Murphy's raw chocolate chip cookie dough or raw s'mores bars dough, and 1 person ate baked chocolate chip cookies made from Papa Murphy's dough.
Papa Murphy's temporarily stopped selling its raw dough on May 23 in response to the outbreak. And the CDC said that, as of July 13, the chain has not restarted sales of cookie dough and is reviewing its dessert labels to make it clear to customers that such products are not intended to be eaten raw.
News brief Stephanie Soucheray, MA Topics COVID-19 In a new report published in Eurosurveillance, Dutch investigators describe an outbreak of COVID-19 in gorillas and lions at the Rotterdam Zoo in late 2021, despite the use of personal protective equipment (PPE) by their zookeepers. SARS-CoV-2 has been detected in several zoo animals, likely caused by human-to-animal transmission. Such transmission has also been documented among domesticated and wild animals. Transmission dynamics must be understood, the authors of the study said, to assess spillover risk and protect animals from SARS-CoV-2 from a One Health perspective. The Rotterdam outbreak occurred during a 6-day period in November 2021, when multiple western lowland gorillas and Asiatic lions experienced fever, coughing and lethargy. Zookeepers had been wearing PPE since 2020, when the COVID-19 pandemic began, and zoo visitors were required to show proof of vaccination, or a negative COVID test result to gain admission. Extensive testing of the animals and 19 staff deemed direct contacts and 21 staff deemed indirect contact suggested human-to-animal transmission. Genomic data of two zookeepers and the lions and gorillas clustered, which may indicate transmission between the animals and their zookeepers, the authors said. "We considered one or multiple asymptomatic infectious zookeepers, who may have had contact with each other in private settings or in the changing rooms, as the most likely outbreak source," the authors said. "Subsequent animal-to-animal transmission is likely given the high attack rate among the animals and the consistent PPE use of the zookeepers." Subsequent animal-to-animal transmission is likely given the high attack rate among the animals. Strict measures should be taken in zoos to protect against SARS-CoV-2 spillover events, the authors conclude. "It is crucial to adopt stringent prevention and control strategies to avoid introduction of respiratory pathogens in animal populations," they write.Animal-to-animal spread likely, too
News brief Chris Dall, MA Topics Antimicrobial Stewardship Influenza Vaccines Pneumonia Reviewing literature published from 1998 through 2021, researchers from the Netherlands Institute for Health Services Research included 29 randomized controlled trials (RCTs) and 69 observational studies in their meta-analysis. Most studies were performed in high-income countries in Europe and the Americas, and outcome measures included the proportion of people receiving antibiotics, the number of antibiotic courses or prescriptions per person, and days of antibiotic use. Results were stratified by global region and age-group. The RCTs showed that the effect of influenza vaccination on the number of antibiotic prescriptions or days of antibiotic use (ratio of means [RoM], 0.71; 95% confidence interval [CI], 0.62 to 0.83) is stronger compared to the effect of pneumococcal vaccination (RoM, 0.92; 95% CI, 0.85 to 1.00) and confirmed a reduction in the proportion of people receiving antibiotics after flu vaccination (risk ratio [RR], 0.63; 95% CI 0.51 to 0.79). The effect of flu vaccination in Europe and the Americas ranged from 0.63 and 0.87 RoM to 0.70 and 0.66 RR, respectively. The evidence from observational studies supported these findings but presented a less consistent picture. These interventions need to be integrated into a multi-pronged strategy that takes into account all of the other factors that can reduce antibiotic use over time. The study authors say the stronger effect of the flu vaccine on antibiotic use is surprising, given that flu should not be treated with antibiotics and that the vaccine effectiveness (VE) of pneumococcal vaccines is considerably higher than the VE of influenza vaccines. Still, they say that both vaccines should be used as a possible public health intervention to address antimicrobial resistance. "These interventions need to be integrated into a multi-pronged strategy that takes into account all of the other factors that can reduce antibiotic use over time, such as antibiotic stewardship policies, raised awareness about rational antibiotic use through antibiotic campaigns and/or access to antimicrobials," they wrote.A systematic review and meta-analysis shows that influenza vaccination is associated with significantly reduced antibiotic use, while the effect of pneumococcal vaccination is less pronounced, Dutch researchers reported today in Antimicrobial Resistance and Infection Control.
News brief Chris Dall, MA Topics Antimicrobial Stewardship An analysis of data from 51 countries highlights the diversity of mechanisms driving antibiotic resistance (ABR), researchers this week in The Lancet Planetary Health. For the study, a team of researchers from France's Institut Pasteur analyzed count data of clinical isolates for 13 drug-bacterium pairs in 51 countries extracted from the ATLAS (Antimicrobial Testing Leadership and Surveillance) system from 2006 through 2019. Their aim was to evaluate ABR spatial-temporal dynamics and identify and compare the key mechanistic factors—including antibiotic sales, meteorologic and climatic variable, wealth and health metrics, and population density—associated with those factors. A total of 808,774 isolates from all infection sources were analyzed. For 2019, median ABR rates ranged from 6.3% for carbapenem-resistant Klebsiella pneumoniae to 80.7% for fluoroquinolone-resistant Acinetobacter baumannii, with variations across countries. The only resistance trend observed from 2006 to 2019 was for drug-bacterium pairs associated with carbapenem resistance, which increased in more than 60% of investigated countries. Key factors associated with ABR rates varied greatly among drug-bacterium pairs. Multivariable analyses identified significant associations of ABR with country-level antibiotic sales, but only in fluoroquinolone-resistant Escherichia coli, fluoroquinolone-resistant Pseudomonas aeruginosa, and carbapenem-resistant A baumannii. There was also a correlation between temperature and resistance in Enterobacteriaceae, between carbapenem-resistant A baumannii and gross domestic product, and with health system quality for all drug-bacterium pairs except Enterococci and Streptococcus pneumoniae pairs Resistances are driven by both individual behaviours and global environmental mechanisms. The authors of the study say the findings show that ABR is a "plural threat." "Despite differences across pathogens, resistances are driven by both individual behaviours and global environmental mechanisms setting ABR in a One Health framework," they wrote. "Therefore, strategies to tackle worldwide antibiotic resistance should be tailored accounting for the species, the resistance, and the epidemiological settings at stake."
News brief Jim Wappes Topics Enterovirus, Non-Polio Public Health To determine the prevalence of respiratory viruses in school students and staff members, researchers tested samples from a large school district in Kansas City that includes 33 pre-kindergarten (pre-K) through grade 12 schools during the 2022-23 school year. Among the 894 study participants, 639 (71.5%) were students (representing 3.0% of total district enrollment), and 255 (28.5%) were staff members (representing 7.1% of the total). Researchers tested 3,232 surveillance specimens, including 872 (27.0%) from staff and 2,360 (73.0%) from students. Among 2,393 completed surveys, pre-K students reported the highest prevalence of having one or more symptoms—41.1%—compared with 14.0% among high school students. Overall, 805 specimens (24.9%) tested positive for any virus (95% confidence interval,23.4% to 26.4%). A substantially higher percentage of pre-K specimens tested positive (40.0%) compared with staff member specimens (14.1%). Among all samples, rhinovirus or enterovirus was most common (found in 12.1% of samples), followed by seasonal coronaviruses (5.6%). It is important to implement strategies to prevent and reduce the spread of infectious diseases. The study authors conclude, "It is important to implement strategies to prevent and reduce the spread of infectious diseases, including staying up to date with recommended vaccinations, including COVID-19 and influenza vaccines, practicing good hand hygiene and respiratory etiquette, staying home when sick, and improving indoor ventilation."Surveillance at a large school district in Kansas City, Missouri, found that 25% of nasal swabs from students and staff tested positive for common non-COVID respiratory viruses, according to a study today in Morbidity and Mortality Weekly Report.
Rhinovirus, enterovirus most common
News brief Lisa Schnirring Topics Mpox Measles Polio
ALL BRIEFS
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This week's top reads
- FDA modifies strain recommendation for fall COVID vaccine amid variant shifts, uptick in cases The CDC estimates that cases are growing or likely growing in 34 states and territories. Lisa Schnirring
- USDA reports reveal biosecurity risks at H5N1-affected dairy farms Shared equipment, shared staff, and animal movements were among key findings for virus spread among different farms. Lisa Schnirring
- Studies find little to no immunity to H5N1 avian flu virus in Americans The CDC said the findings aren't surprising, given that the virus hasn't spread widely in people and is very different from seasonal flu strains. Lisa Schnirring
- COMMENTARY: Misleading BMJ Public Health paper on COVID-19 excess mortality needs to be retracted The paper has already led to much confusion and has been used as fodder for anti-vaccine advocates. Lone Simonsen Rasmus Pedersen
- Study details reduced Tamiflu susceptibility in H1N1 flu cases The Netherlands had the most detections. Stephanie Soucheray
- Study identifies female sex, heart disease as long-COVID risk factors, vaccination as protective The researchers also show that more than 1 in 5 adults had protracted recoveries. Mary Van Beusekom
- CDC data show uptick in COVID-19 cases, low flu activity COVID test positivity, emergency department visits, hospitalizations, and deaths are are on the rise, but remain at low levels. Chris Dall
- NIAID experiments show H5N1 levels plummet after heat treatment, but not to zero in some cases Researchers emphasized that the findings reflect experimental lab conditions and don't reflect large-scale industrial pasteurization of raw milk. Lisa Schnirring
- China reports another fatal H5N6 avian flu case Officials didn't say how the man contracted the virus, but most past cases involved contact with poultry or poultry environments. Lisa Schnirring
- Cannabis use linked to worse COVID-19 outcomes Cannabis use was significantly associated with increased risk of hospitalization. Stephanie Soucheray
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