SASSAFRAS: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (2024)

Overview

Sassafras is a plant. The root bark is used to make medicine.

Despite serious safety concerns, people use sassafras for many conditions, but there is no good scientific evidence to support these uses.

In beverages and candy, sassafras was used in the past to flavor root beer. It was also used as a tea. But sassafras tea contains a lot of safrole, the chemical in sassafras that makes it poisonous. One cup of tea made with 2.5 grams of sassafras contains about 200 mg of safrole. This is about 4.5 times the dose that researchers think is poisonous. So, in 1976, the US Food and Drug Administration (FDA) ruled that sassafras could no longer be sold as sassafras tea.

How does it work ?

There isn't enough information available to know how sassafras works.

There isn't enough information available to know how sassafras works.

Uses & Effectiveness ?

Insufficient Evidence for

  • Urinary tract problems.
  • Gout.
  • Arthritis.
  • Skin problems.
  • Eye swelling.
  • Sprains.
  • Insect bites and stings.
  • Purifying the blood.
  • Other conditions.

More evidence is needed to rate the effectiveness of sassafras for these uses.

Side Effects

When taken by mouth: Sassafras is POSSIBLY SAFE in foods and beverages if it is "safrole-free." In medicinal amounts, taking safrole-free sassafras is POSSIBLY UNSAFE. Some scientists think even safrole-free sassafras can increase the risk of cancer. Sassafras containing safrole is LIKELY UNSAFE in the amounts found in medicine. Don't take it by mouth. The safrole in sassafras root bark and oil can cause cancer and liver damage. Consuming just 5 mL of sassafras oil can kill an adult. Sassafras can cause sweating and hot flashes. High amounts can cause vomiting, high blood pressure, hallucinations, and other severe side effects.

When applied to the skin: Sassafras containing safrole is LIKELY UNSAFE for use as a medicine. Don't put it on your skin. The safrole in sassafras root bark and oil can cause cancer and liver damage. It can cause skin rashes in some people when used on the skin.

Special Precautions and Warnings

When taken by mouth: Sassafras is POSSIBLY SAFE in foods and beverages if it is "safrole-free." In medicinal amounts, taking safrole-free sassafras is POSSIBLY UNSAFE. Some scientists think even safrole-free sassafras can increase the risk of cancer. Sassafras containing safrole is LIKELY UNSAFE in the amounts found in medicine. Don't take it by mouth. The safrole in sassafras root bark and oil can cause cancer and liver damage. Consuming just 5 mL of sassafras oil can kill an adult. Sassafras can cause sweating and hot flashes. High amounts can cause vomiting, high blood pressure, hallucinations, and other severe side effects.

When applied to the skin: Sassafras containing safrole is LIKELY UNSAFE for use as a medicine. Don't put it on your skin. The safrole in sassafras root bark and oil can cause cancer and liver damage. It can cause skin rashes in some people when used on the skin. It is UNSAFE for anyone to use sassafras in medicinal amounts, but some people have extra reasons not to use it:

Pregnancy and breast-feeding: Sassafras is LIKELY UNSAFE if you are pregnant. There is evidence that sassafras oil might cause a miscarriage. There isn't enough reliable information to know if it is safe to use when breast-feeding. Stay on the safe side and avoid use.

Children: Sassafras is LIKELY UNSAFE for children. A few drops of sassafras oil may be deadly.

Surgery: In medicinal amounts, sassafras can slow down the central nervous system. This means it can cause sleepiness and drowsiness. When combined with anesthesia and other medications used during and after surgery, it might slow down the central nervous system too much. Stop using sassafras at least 2 weeks before a scheduled surgery.

Urinary tract conditions: Sassafras might make these conditions worse.

Interactions ?

    Moderate Interaction

    Be cautious with this combination

  • Sedative medications (CNS depressants) interacts with SASSAFRAS

    Sassafras might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking sassafras along with sedative medications might cause too much sleepiness.

    Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

  • Medications that increase break down of other medications by the liver (Cytochrome P450 CYP1A2 (CYP1A2) inducers) interacts with SASSAFRAS

    Some medications increase breakdown of other medications by the liver. Taking sassafras along with medications that increase breakdown of other medications by the liver might cause chemicals in sassafras to be metabolized to more toxic forms. Some medications that might increase the breakdown of chemicals in sassafras include omeprazole (Prilosec) and others.

Dosing

The appropriate dose of sassafras depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for sassafras. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circ*mstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

SASSAFRAS: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (2024)

FAQs

What are the side effects of sassafras tea? ›

Sassafras can cause sweating and hot flashes. High amounts can cause vomiting, high blood pressure, hallucinations, and other severe side effects. When applied to the skin: Sassafras containing safrole is LIKELY UNSAFE for use as a medicine.

What does sassafras do for the body? ›

Overview. Sassafras is a plant. The root bark is used to make medicine. Despite serious safety concerns, sassafras is used for urinary tract disorders, swelling in the nose and throat, syphilis, bronchitis, high blood pressure in older people, gout, arthritis, skin problems, and cancer.

What are the medical uses for sassafras? ›

For Healthcare Professionals. Sassafras is a perennial tree native to Eastern United States. Native Americans used infusions made from its root bark as a remedy to treat fevers, diarrhea, and rheumatism. It was also used to scent perfume and even as a flavoring for root beer.

What is the sassafras tree used for? ›

In addition to this variety of medicinal uses, sassafras was used for food, construction and other purposes. The leaves were used fresh as a spice, much like bay leaves, for flavoring in meat soups. Leaves were dried and pounded and used as a thickening agent and to add flavor to foods and soups.

Can you drink sassafras tea everyday? ›

While the amount of sassafras that could potentially cause cancer in humans remains unknown, one cup of strong sassafras tea is reported to contain as much as 200 mg of safrole, an amount that is four times higher than the amount considered potentially hazardous to humans if consumed regularly.

Does sassafras help with inflammation? ›

Sassafras tea is produced from the root bark of the sassafras tree, which is native to parts of North America and Eastern Asia. Test-tube studies show that sassafras and its components may reduce inflammation, act as a diuretic, and help treat leishmaniasis, a parasitic infection.

Does sassafras tea clean your blood? ›

Sassafras had many medicinal uses as a tea to purify blood and heal ailments including skin diseases, rheumatism, venereal disease, and ague. The roots and berries made a tea to treat nausea, fevers, fatigue, gas pains, menstrual pains, and syphilis.

Is sassafras good for arthritis? ›

Anti-inflammatory - one of the oldest applications of sassafras is for fever reduction but of course is also used for gastrointestinal inflammation, arthritis, headaches, as well as more serious conditions such as gout or rheumatism.

What happens when you take sassafras? ›

As a result of the drug's action in the brain, the individual who uses sassafras, particularly sassafras oil or safrole, may experience the following harmful health effects, according to WebMD: Hallucinations. High blood pressure. Hot flashes and sweating.

Why isn t sassafras used anymore? ›

Well, sassafras and sarsaparilla both contain safrole, a compound recently banned by the FDA due to its carcinogenic effects. Safrole was found to contribute to liver cancer in rats when given in high doses, and thus it and sassafras or sarsaparilla-containing products were banned.

What food is sassafras used for? ›

Sassafras is the main ingredient in traditional drinks, root beer, sweets and root tea. Ground sassafras leaves are used for their thickening and flavouring qualities. Native Americans used sassafras leaves as a fresh spice, like bay leaves, in soups and meat stews.

Is sassafras the same as sarsaparilla? ›

Both beverages are named after their distinct differences in ingredients when they were first made. Sarsaparilla was made from the Sarsaparilla vine, while Root Beer, roots of the sassafras tree. These days, Root Beer recipes do not include sassafras as the plant has been found to cause serious health issues.

Can you eat raw sassafras? ›

The twigs and leaves are both edible, and can be eaten raw or added to soups for flavor. Although it seems strange, dried sassafras leaves are actually very important spice in some dishes. Native Americans and early colonists, however, did not use sassafras roots for pleasure or spices; they used them as medicine!

How much sassafras is in root beer? ›

While sassafras is no longer used in commercially produced root beer and is sometimes replaced with artificial flavors, natural extracts with the safrole distilled and removed are available.

Are bay leaf and sassafras the same thing? ›

Sassafras is in the Laurel family, making it related to the plants that produce cinnamon and bay leaves. Due to its aromatic nature, Sassafras has a number of culinary uses. Sassafras root was used to flavor the original root beer, sarsaparilla.

Why did they stop using sassafras? ›

Well, sassafras and sarsaparilla both contain safrole, a compound recently banned by the FDA due to its carcinogenic effects. Safrole was found to contribute to liver cancer in rats when given in high doses, and thus it and sassafras or sarsaparilla-containing products were banned.

Is sassafras tea good for your stomach? ›

Sassafras has been used for centuries to treat multiple conditions ranging from blood purifications to stomach complaints, particularly by various Native American tribes. Some folk medicine techniques involved creating sassafras tea to treat liver, kidney and chest problems.

What did Native Americans use sassafras for? ›

Indigenous Uses

Sassafras had many medicinal uses as a tea to purify blood and heal ailments including skin diseases, rheumatism, venereal disease, and ague. The roots and berries made a tea to treat nausea, fevers, fatigue, gas pains, menstrual pains, and syphilis.

Is sassafras tea a blood thinner? ›

The bark of roots was used to make sassafras tea and to flavor root beer. "Aromatic sassafras tea, once popular as a stimulant and blood thinner and as a reputed cure for rheumatism and syphilis, causes cancer in rats when taken in large amounts.

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